Scott R T
Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, Livingston, NJ 07039, USA.
Semin Reprod Endocrinol. 1996 Nov;14(4):317-37. doi: 10.1055/s-2008-1067977.
Identification and treatment of low responders to ovulation induction is one of the most frustrating challenges in reproductive medicine. Because complex ovulation induction is required so frequently and is so expensive, efficient diagnosis of hyporesponders is critical. At present, the best techniques of evaluating ovarian reserve are basal follicle-stimulating hormone/Estradiol levels early in the proliferative phase and the clomiphene citrate challenge test. When poor responders are identified, strong consideration should be given to adjunctive approaches such as gonadotropin-releasing hormone analog and microdose flare or possibly, embryo hatching in those women undergoing in vitro fertilization.
识别和治疗对促排卵反应低下者是生殖医学中最令人沮丧的挑战之一。由于复杂的促排卵常常是必需的且费用高昂，因此高效诊断反应低下者至关重要。目前，评估卵巢储备的最佳技术是增殖期早期的基础促卵泡激素/雌二醇水平以及枸橼酸氯米芬激发试验。当识别出反应低下者时，应强烈考虑辅助方法，如促性腺激素释放激素类似物和微剂量激发方案，对于接受体外受精的女性，可能还需考虑胚胎孵化。
