人类卵母细胞体外成熟技术在低反应患者中的潜在应用。
The potential use of maturation in vitro of human oocytes in low responder patients.
作者信息
Requena A, Neuspiller F, Cobo A C, Aragonés M, Remohí J, Simón C, Pellicer A
机构信息
Instituto Valenciano de Infertilidad, Spain.
出版信息
J Assist Reprod Genet. 2000 May;17(5):239-44. doi: 10.1023/a:1009405730750.
PURPOSE
To assess whether maturation in vitro of human oocytes (MIVHO) could be an alternative treatment in low responders to ovarian stimulation for in vitro fertilization (IVF).
METHODS
Prospective case-control study. Spontaneously ovulatory women who volunteered were included in our program of MIVHO at the Instituto Valenciano de Infertilidad. Rates of oocyte retrieval, in vitro maturation, fertilization, and development up to the blastocyst stage were studied.
RESULTS
A significantly increased rate of oocyte retrieval was found when the pickup was performed before follicular selection. No differences were found when MIVHO was used in a low responder patient with an ovarian content of early antral follicles > 5 as compared to normal responders.
CONCLUSIONS
MIVHO could be a successful choice in low responder patients with an acceptable number of early antral follicles. Oocyte retrieval should be performed before follicular selection in order to obtain more oocytes.
目的
评估人类卵母细胞体外成熟（MIVHO）是否可作为体外受精（IVF）卵巢刺激低反应者的一种替代治疗方法。
方法
前瞻性病例对照研究。在瓦伦西亚不育研究所，自愿参与的自然排卵女性被纳入我们的MIVHO项目。研究了卵母细胞采集、体外成熟、受精以及发育至囊胚阶段的比率。
结果
在卵泡选择前进行采集时，发现卵母细胞采集率显著提高。与正常反应者相比，在早期窦卵泡数量>5的卵巢低反应患者中使用MIVHO时未发现差异。
结论
对于早期窦卵泡数量可接受的低反应患者，MIVHO可能是一种成功的选择。为了获得更多卵母细胞，应在卵泡选择前进行卵母细胞采集。
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