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本文引用的文献

1
Maturation in vitro of human oocytes from unstimulated cycles: selection of the optimal day for ovum retrieval based on follicular size.未刺激周期中人类卵母细胞的体外成熟：基于卵泡大小选择取卵的最佳日期。
Hum Reprod. 1999 Jul;14(7):1864-8. doi: 10.1093/humrep/14.7.1864.
2
Evaluation of the ovarian reserve in young low responders with normal basal levels of follicle-stimulating hormone using three-dimensional ultrasonography.
Fertil Steril. 1998 Oct;70(4):671-5. doi: 10.1016/s0015-0282(98)00268-4.
3
Immature oocyte retrieval: lessons from unstimulated IVF cycles.未成熟卵母细胞取卵：未刺激体外受精周期的经验教训。
Fertil Steril. 1998 Oct;70(4):647-50. doi: 10.1016/s0015-0282(98)00274-x.
4
Use of the antral follicle count to predict the outcome of assisted reproductive technologies.使用窦卵泡计数来预测辅助生殖技术的结果。
Fertil Steril. 1998 Mar;69(3):505-10. doi: 10.1016/s0015-0282(97)00557-8.
5
Embryonic regulation of integrins beta 3, alpha 4, and alpha 1 in human endometrial epithelial cells in vitro.体外人子宫内膜上皮细胞中整合素β3、α4和α1的胚胎调控
J Clin Endocrinol Metab. 1997 Aug;82(8):2607-16. doi: 10.1210/jcem.82.8.4153.
6
Pregnancy and birth rates after oocyte donation.
Fertil Steril. 1997 Apr;67(4):717-23. doi: 10.1016/s0015-0282(97)81372-6.
7
Unstimulated immature oocyte retrieval: early versus midfollicular endometrial priming.
Fertil Steril. 1997 Apr;67(4):616-20. doi: 10.1016/s0015-0282(97)81354-4.
8
Poor responders to ovarian hyperstimulation may benefit from an attempt at natural-cycle oocyte retrieval.对卵巢过度刺激反应不佳的患者可能会从尝试自然周期取卵中获益。
J Assist Reprod Genet. 1997 Mar;14(3):174-6. doi: 10.1007/BF02766136.
9
Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization.
Hum Reprod. 1997 Feb;12(2):220-3. doi: 10.1093/humrep/12.2.220.
10
Manipulation of human ovarian function: physiological concepts and clinical consequences.人类卵巢功能的调控：生理概念与临床后果
Endocr Rev. 1997 Feb;18(1):71-106. doi: 10.1210/edrv.18.1.0290.

人类卵母细胞体外成熟技术在低反应患者中的潜在应用。

The potential use of maturation in vitro of human oocytes in low responder patients.

作者信息

Requena A, Neuspiller F, Cobo A C, Aragonés M, Remohí J, Simón C, Pellicer A

机构信息

Instituto Valenciano de Infertilidad, Spain.

出版信息

J Assist Reprod Genet. 2000 May;17(5):239-44. doi: 10.1023/a:1009405730750.

DOI:10.1023/a:1009405730750
PMID:10976409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455207/
Abstract

PURPOSE

To assess whether maturation in vitro of human oocytes (MIVHO) could be an alternative treatment in low responders to ovarian stimulation for in vitro fertilization (IVF).

METHODS

Prospective case-control study. Spontaneously ovulatory women who volunteered were included in our program of MIVHO at the Instituto Valenciano de Infertilidad. Rates of oocyte retrieval, in vitro maturation, fertilization, and development up to the blastocyst stage were studied.

RESULTS

A significantly increased rate of oocyte retrieval was found when the pickup was performed before follicular selection. No differences were found when MIVHO was used in a low responder patient with an ovarian content of early antral follicles > 5 as compared to normal responders.

CONCLUSIONS

MIVHO could be a successful choice in low responder patients with an acceptable number of early antral follicles. Oocyte retrieval should be performed before follicular selection in order to obtain more oocytes.

摘要

目的

评估人类卵母细胞体外成熟（MIVHO）是否可作为体外受精（IVF）卵巢刺激低反应者的一种替代治疗方法。

方法

前瞻性病例对照研究。在瓦伦西亚不育研究所，自愿参与的自然排卵女性被纳入我们的MIVHO项目。研究了卵母细胞采集、体外成熟、受精以及发育至囊胚阶段的比率。

结果

在卵泡选择前进行采集时，发现卵母细胞采集率显著提高。与正常反应者相比，在早期窦卵泡数量>5的卵巢低反应患者中使用MIVHO时未发现差异。

结论

对于早期窦卵泡数量可接受的低反应患者，MIVHO可能是一种成功的选择。为了获得更多卵母细胞，应在卵泡选择前进行卵母细胞采集。