Marchenko V I, Zubanova N A, Diuĭsalieva R G, Voronina F V, Delimbetova G A
Vopr Virusol. 1977 Mar-Apr(2):206-15.
Experiments revealed parallelism between the duration of the main manifestations of the hyporeactivity phenomenon (tolerance) in interferon induction and the duration of detection of a masked infection with the inducer virus (Newcastle disease virus) in peritoneal exudate cells of tolerant mice. It was also shown that after contact of chick fibroblasts with a dose of interferon which completely inhibited replication of vesicular stomatitis virus infecting the cells this virus was found in the cells in the masked form. Persistence of a virus interferon inducer in the masked form appears to play a significant role in the mechanism of tolerance as well as creation in the interferon-treated cells of conditions for masking viruses infecting these cells.
实验揭示了干扰素诱导中低反应性现象（耐受性）主要表现的持续时间与耐受小鼠腹膜渗出细胞中诱导病毒（新城疫病毒）隐性感染的检测持续时间之间的平行关系。还表明，鸡成纤维细胞与完全抑制感染细胞的水疱性口炎病毒复制的一定剂量干扰素接触后，该病毒以隐性形式存在于细胞中。病毒干扰素诱导剂以隐性形式持续存在似乎在耐受机制以及在经干扰素处理的细胞中创造隐性感染这些细胞的病毒的条件方面发挥着重要作用。
