Culubret M, Roig I
Department of Surgical Pathology, Consorci Sanitari de Terrassa, Barcelona, Spain.
Diagn Cytopathol. 1996 Dec;15(5):431-4. doi: 10.1002/(SICI)1097-0339(199612)15:5<431::AID-DC15>3.0.CO;2-O.
We describe the cytologic findings of a fine-needle aspiration (FNA) breast lesion with a typical histology for adenoid cystic carcinoma. The aspirate yielded highly cellular smears with a monomorphic population of small, slightly atypical cells, arranged in multilayered groups with abundant fine intercellular metachromatic substance between cell groups. There were also fragments of fibrillar stroma in close relation to epithelial cells. The diagnosis based on the FNA material was suspicious of malignancy. The cytomorphology in this case presented a difficult differential diagnosis with pleomorphic adenoma. Features indicative of adenoid cystic carcinoma were nuclear cell hyperchromasia, the presence of small nucleoli, and scant, poorly defined, or absent cytoplasms. Differential diagnosis of breast adenoid cystic carcinoma with other entities will also be discussed.
我们描述了一例细针穿刺（FNA）乳腺病变的细胞学表现，其具有腺样囊性癌的典型组织学特征。吸出物涂片细胞丰富，有一群形态单一的小细胞，略显非典型，呈多层排列，细胞团之间有丰富的细颗粒状异染性物质。还有与上皮细胞紧密相关的纤维性间质碎片。根据FNA材料做出的诊断怀疑为恶性。该病例的细胞形态学表现与多形性腺瘤的鉴别诊断存在困难。提示腺样囊性癌的特征包括细胞核深染、存在小核仁以及细胞质稀少、界限不清或缺乏。还将讨论乳腺腺样囊性癌与其他实体的鉴别诊断。
