Orlandi C
Medco Research, Inc., Research Triangle Park, NC 27709, USA.
J Nucl Cardiol. 1996 Nov-Dec;3(6 Pt 2):S27-30. doi: 10.1016/s1071-3581(96)90205-6.
Successful scintigraphic imaging of coronary artery stenosis is dependent on detecting regional differences (nonhomogeneous distribution) in coronary blood flow that can be induced by physiologic or pharmacologic stress. Table 1 represents a summary of major pharmacologic responses of the heart to the four agents discussed above. Both adenosine and dipyridamole produce superior coronary vasodilation and tend to be preferred for use in single-photon emission computed tomography, whereas dobutamine and arbutamine provoke a marked ischemic response and tend to be preferred for use in echocardiography. Which agent employed remains a judgment of the physician based on known side effects of these agents, the patient's ability to tolerate these side effects, and the nature of the test desired.
冠状动脉狭窄的成功闪烁成像取决于检测冠状动脉血流中的区域差异（非均匀分布），这种差异可由生理或药物应激诱发。表1总结了心脏对上述四种药物的主要药理反应。腺苷和双嘧达莫均可产生较好的冠状动脉血管舒张作用，在单光子发射计算机断层扫描中往往更受青睐，而多巴酚丁胺和阿巴丁胺会引发明显的缺血反应，在超声心动图检查中往往更受青睐。选用哪种药物仍由医生根据这些药物已知的副作用、患者耐受这些副作用的能力以及所需检查的性质来判断。
