Adány R
Department of Hygiene and Epidemiology, University School of Medicine, Debrecen, Hungary.
Semin Thromb Hemost. 1996;22(5):399-408.
In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).
除了血浆中作为四聚体纤维蛋白稳定因子异二聚体一部分存在的因子 XIII A 亚基外，在不同人体组织的细胞定位中也可检测到因子 XIII A 的同二聚体。实验结果证实，这些细胞属于巨核细胞/血小板和单核细胞/巨噬细胞系。此外，因子 XIII A 存在于主要位于肝脏中央静脉周围的肝细胞中，偶尔也在某些恶性转化细胞中表达。有理由推测，因子 XIII A 不仅作为凝血级联反应的一员发挥作用，还作为一种细胞内酶，能够在细胞内（在细胞骨架的组装/重新组装过程中）或细胞外（在含有它的细胞周围的结缔组织基质中）催化分子相互作用。
