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A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor.

作者信息

Dranoff G, Soiffer R, Lynch T, Mihm M, Jung K, Kolesar K, Liebster L, Lam P, Duda R, Mentzer S, Singer S, Tanabe K, Johnson R, Sober A, Bhan A, Clift S, Cohen L, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Mulligan R C

机构信息

Dana-Farber Cancer Institute, Boston, MA, USA.

出版信息

Hum Gene Ther. 1997 Jan 1;8(1):111-23. doi: 10.1089/hum.1997.8.1-111.

DOI:10.1089/hum.1997.8.1-111
PMID:8990000
Abstract
摘要

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1
A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor.一项关于用经基因工程改造以分泌人粒细胞巨噬细胞集落刺激因子的自体辐照黑素瘤细胞进行疫苗接种的I期研究。
Hum Gene Ther. 1997 Jan 1;8(1):111-23. doi: 10.1089/hum.1997.8.1-111.
2
Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.通过腺病毒介导的基因转移工程改造的经辐射的自体黑色素瘤细胞进行疫苗接种，可增强转移性黑色素瘤患者的抗肿瘤免疫力，这些细胞被设计用于分泌粒细胞巨噬细胞集落刺激因子。
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3
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.用经基因工程改造以分泌人粒细胞巨噬细胞集落刺激因子的辐照自体黑色素瘤细胞进行疫苗接种，可在转移性黑色素瘤患者中产生强大的抗肿瘤免疫力。
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Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.由经基因工程改造以分泌粒细胞巨噬细胞集落刺激因子或Flt3配体的肿瘤在体内刺激的树突状细胞的差异。
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Immunogenetic therapy of human melanoma utilizing autologous tumor cells transduced to secrete granulocyte-macrophage colony-stimulating factor.利用转导以分泌粒细胞巨噬细胞集落刺激因子的自体肿瘤细胞对人类黑色素瘤进行免疫基因治疗。
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Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma.采用腺病毒介导基因转移工程改造的自体照射黑色素瘤细胞进行疫苗接种的II期试验，用于III期和IV期黑色素瘤患者，该工程细胞可分泌粒细胞巨噬细胞集落刺激因子
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