Lobbezoo F, Lavigne G J, Tanguay R, Montplaisir J Y
Département de Physiologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
Mov Disord. 1997 Jan;12(1):73-8. doi: 10.1002/mds.870120113.
The putative role of the dopaminergic system in sleep bruxism (SB) was studied in a double-blind clinical trial by using low doses of short-term L-dopa in combination with benserazide. We recorded 10 patients with SB in our sleep laboratory for 3 consecutive nights. The first night was for habituation to the laboratory environment. During the second and the third nights, the patients received two doses of either L-dopa or a placebo in a crossover fashion: the first dose 1 h before bedtime and the second, 4 h after the first one. The order of administration was reversed in half the patients. The efficacy of L-dopa was analyzed by using multilevel models. L-Dopa resulted in a significant decrease in the average number of bruxism episodes per hour of sleep, as well as in a significant reduction in the average value of the root-mean-square (RMS) electromyography (EMG) level per bruxism burst. This indicates that L-dopa exerts an attenuating effect on SB. In addition, L-dopa caused a reduction in the variance in RMS values, which suggests that L-dopa normalizes the EMG activity patterns associated with SB.
在一项双盲临床试验中，通过使用低剂量短期左旋多巴联合苄丝肼，研究了多巴胺能系统在睡眠磨牙症（SB）中的假定作用。我们在睡眠实验室对10名睡眠磨牙症患者连续记录了3个晚上。第一个晚上用于让患者适应实验室环境。在第二个和第三个晚上，患者以交叉方式接受两剂左旋多巴或安慰剂：第一剂在睡前1小时服用，第二剂在第一剂服用后4小时服用。一半患者的给药顺序相反。使用多级模型分析左旋多巴的疗效。左旋多巴导致每小时睡眠中磨牙发作的平均次数显著减少，以及每次磨牙发作时肌电图（EMG）均方根（RMS）水平的平均值显著降低。这表明左旋多巴对睡眠磨牙症有减轻作用。此外，左旋多巴导致RMS值的方差减小，这表明左旋多巴使与睡眠磨牙症相关的肌电图活动模式正常化。
