Wetter T C, Trenkwalder C, Stiasny K, Pollmächer T, Kazenwadel J, Kohnen R, Künzel M, Oertel W H
Max-Planck-Institut für Psychiatrie, Klinischen Instituts, München, Deutschland.
Wien Med Wochenschr. 1995;145(17-18):525-7.
In a randomized, controlled and double-blind cross-over trial with L-Dopa and placebo we evaluated the effects of a single bedtime dose of L-Dopa 100 to 200 mg on sleep quality and frequency of periodic leg movements (PLM) in 17 patients with idiopathic and in 11 patients with uremic restless legs syndrome (RLS) by polysomnography, actigraphy, and subjective ratings. Treatment with L-Dopa showed significant reduction of the number of periodic leg movements and the PLM-index most pronounced during the first 4 hours of bedtime. Subjective evaluation confirmed improvement of sleep quality. L-Dopa proved to be effective in idiopathic and uremic RLS without any severe side effects.
在一项使用左旋多巴和安慰剂的随机、对照、双盲交叉试验中，我们通过多导睡眠图、活动记录仪和主观评分，评估了17例特发性不安腿综合征患者和11例尿毒症不安腿综合征（RLS）患者在睡前单次服用100至200毫克左旋多巴对睡眠质量和周期性腿部运动（PLM）频率的影响。左旋多巴治疗使周期性腿部运动的数量和PLM指数显著降低，在睡前的前4小时最为明显。主观评估证实睡眠质量有所改善。左旋多巴被证明对特发性和尿毒症性RLS有效，且无任何严重副作用。
