嗜热自养甲烷杆菌δ(H)中5-氨基咪唑-4-甲酰胺核糖核苷酸和N-(β-D-呋喃核糖基)甲酰胺5'-磷酸的产生及生物合成
Occurrence and biosynthesis of 5-aminoimidazole-4-carboxamide ribonucleotide and N-(beta-D-ribofuranosyl)formamide 5'-phosphate in Methanobacterium thermoautotrophicum delta(H).
作者信息
White R H
机构信息
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308, USA.
出版信息
J Bacteriol. 1997 Jan;179(2):563-6. doi: 10.1128/jb.179.2.563-566.1997.
Abstract
5-Aminoimidazole-4-carboxamide ribonucleotide (ZMP) and N-(beta-D-ribofuranosyl)formamide 5'-phosphate (FAR-P) have been identified as products of the metabolism of ATP and 5-phospho-alpha-D-ribosyl diphosphate by Methanobacterium thermoautotrophicum delta(H), a member of the domain Archaea. Evidence indicates that the first three steps in the pathway to the formation of these compounds are the same as the first three steps of histidine biosynthesis and lead to the generation of pro-phosphoribosyl formimino-5-aminoimidazole-4-carboxamide ribonucleotide (5'-proFAR). The 5'-proFAR then undergoes hydrolysis to ZMP and FAR-P. The reaction was detected by an unexpected high concentration of ZMP in cell extracts of M. thermoautotrophicum delta(H).
摘要
5-氨基咪唑-4-甲酰胺核糖核苷酸（ZMP）和N-（β-D-呋喃核糖基）甲酰胺5'-磷酸（FAR-P）已被鉴定为嗜热自养甲烷杆菌δ（H）（古菌域的一个成员）对ATP和5-磷酸-α-D-核糖基二磷酸进行代谢的产物。有证据表明，这些化合物形成途径的前三个步骤与组氨酸生物合成的前三个步骤相同，并导致生成前磷酸核糖基甲脒基-5-氨基咪唑-4-甲酰胺核糖核苷酸（5'-proFAR）。然后5'-proFAR水解生成ZMP和FAR-P。该反应是通过嗜热自养甲烷杆菌δ（H）细胞提取物中意外高浓度的ZMP检测到的。
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