Takahashi Y, Okamura A, Yasoshima K, Koike A
Department of Pediatrics, Tonan Hospital.
Arerugi. 1996 Nov;45(11):1161-5.
We measured serum ECP levels in infants during first wheezing episode. Serum ECP in these infants are significantly higher than in control infants, although much higher in children with asthma. Serum ECP in these infants with high serum IgE and/or positive RAST score are higher than in infants with normal serum IgE and negative RAST score. In children with bronchial asthma serum ECP is correlated with peripheral eosinophil counts, but in infants during first wheezing episode serum ECP is often elevated not associated with increased peripheral eosinophil counts. These suggest that activated eosinophils could be responsible for bronchoconstriction in wheezing patients with atopic diathesis even in very early phase and that these eosinophilic inflammations could contribute to formation of increased airway reactivity and bronchial asthma.
我们在婴儿首次喘息发作期间测量了血清嗜酸性粒细胞阳离子蛋白（ECP）水平。这些婴儿的血清ECP水平显著高于对照婴儿，不过哮喘儿童的血清ECP水平更高。血清IgE高和/或RAST评分呈阳性的这些婴儿的血清ECP水平高于血清IgE正常且RAST评分呈阴性的婴儿。在支气管哮喘患儿中，血清ECP与外周血嗜酸性粒细胞计数相关，但在首次喘息发作的婴儿中，血清ECP常常升高，且与外周血嗜酸性粒细胞计数增加无关。这些表明，即使在非常早期阶段，活化的嗜酸性粒细胞也可能是特应性体质喘息患者支气管收缩的原因，且这些嗜酸性粒细胞炎症可能有助于气道反应性增加和支气管哮喘的形成。
