Hasegawa M, Fujisawa T, Komada M, Uchida Y, Haibara C
Department of Pediatrics, Mie National Hospital.
Arerugi. 1991 Mar;40(3 Pt 1):173-80.
We investigated the possibility of a relationship between the serum levels of eosinophil cationic protein (ECP) and the clinical parameters in asthma. A specific question was whether or not serum ECP changes with a circadian rhythm. Eighty nine children with bronchial asthma and sixteen normal, non-atopic subjects were studied. Serum ECP, eosinophil counts (Eo) and pulmonary functions were measured 4 or 5 times a day. ECP was quantitated by a specific radioimmunoassay. Serum ECP and Eo were significantly higher in the patients with bronchial asthma than in non-atopic subjects. Serum ECP levels were higher during asthma attacks and at 24 hours after attacks than those in stable conditions (free of attacks for more than 7 days). Although no circadian rhythm was observed in ECP changes, the patients with bronchial asthma showed a significantly greater variation of serum ECP levels than the non-atopic subjects. There was no significant correlation between serum ECP levels and 2- or 8-week attack score before the ECP measurement. These results suggest that serum ECP increases in bronchial asthma, especially in its acute exacerbation phase, and may reflect eosinophil activation in vivo.
我们研究了哮喘患者血清嗜酸性粒细胞阳离子蛋白（ECP）水平与临床参数之间存在关联的可能性。一个具体问题是血清ECP是否随昼夜节律变化。我们对89名支气管哮喘儿童和16名正常非特应性受试者进行了研究。每天测量4或5次血清ECP、嗜酸性粒细胞计数（Eo）和肺功能。ECP通过特定的放射免疫测定法定量。支气管哮喘患者的血清ECP和Eo显著高于非特应性受试者。哮喘发作期间及发作后24小时的血清ECP水平高于稳定状态（无发作超过7天）时的水平。虽然未观察到ECP变化的昼夜节律，但支气管哮喘患者血清ECP水平的变化幅度显著大于非特应性受试者。在测量ECP之前，血清ECP水平与2周或8周发作评分之间无显著相关性。这些结果表明，支气管哮喘患者血清ECP升高，尤其是在急性加重期，并且可能反映体内嗜酸性粒细胞的激活。
