Panagakos F S, Aboyoussef H, Dondero R, Jandinski J J
Department of Prosthodontics and Biomaterials, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07013, USA.
Int J Oral Maxillofac Implants. 1996 Nov-Dec;11(6):794-9.
Peri-implantitis has been shown to possess clinical characteristics similar to those of periodontitis. This pilot study was conducted to determine levels of inflammatory cytokines in crevicular fluid from healthy implants and those implants affected by peri-implantitis. Fifty implants from 13 patients were examined. A clinical examination was performed, and gingival crevicular fluid samples were collected and analyzed for cytokines. Implants were categorized clinically as healthy, early peri-implantitis, or advanced peri-implantitis. Interleukin-1 beta was detected in the crevicular fluid of implants in all three groups (healthy = 59.47 +/- 15.55 pg/site; early peri-implantitis = 460.77 +/- 35.67 pg/site; and advanced peri-implantitis = 191.10 +/- 21.60 pg/site [mean +/- SEM]). These results indicate that interleukin-1 beta is present in implant gingival crevicular fluid and may be modulating attachment loss in implants suffering from peri-implantitis. Thus, interleukin-1 beta may be used to monitor disease progression.
种植体周围炎已被证明具有与牙周炎相似的临床特征。本初步研究旨在确定健康种植体以及受种植体周围炎影响的种植体龈沟液中炎性细胞因子的水平。对13例患者的50颗种植体进行了检查。进行了临床检查，并收集龈沟液样本分析细胞因子。种植体在临床上分为健康、早期种植体周围炎或晚期种植体周围炎。在所有三组种植体的龈沟液中均检测到白细胞介素-1β（健康组=59.47±15.55 pg/位点；早期种植体周围炎组=460.77±35.67 pg/位点；晚期种植体周围炎组=191.10±21.60 pg/位点[平均值±标准误]）。这些结果表明，白细胞介素-1β存在于种植体龈沟液中，可能在患有种植体周围炎的种植体中调节附着丧失。因此，白细胞介素-1β可用于监测疾病进展。
