Simone J, Schneider G T, Begneaud W, Harms K
Department of Obstetrics and Gynecology, Ochsner Clinic, New Orleans, USA.
J La State Med Soc. 1996 Dec;148(12):539-41.
Granular cell tumors are an uncommon neoplasm of neural origin. They occur throughout the body; only about 10% are found in the vulvar region. Granular cell tumors are most frequent in the third and fourth decade of life, the African-American race, and the female. Generally, they appear as small, firm, painless, slow-growing subcutaneous nodules. They are rarely encapsulated and recurrence is common. The malignant granular cell tumor is rare, representing 1% to 2% of cases. This form is highly aggressive, unresponsive to treatment, and ultimately fatal. A third type of granular cell tumor has been described which has benign pathologic characteristics but behaves in a clinically malignant manner. The treatment of choice for all types is wide, local surgical excision. A case is described which typifies the benign type granular cell tumor.
颗粒细胞瘤是一种罕见的神经源性肿瘤。它们可发生于全身各处；仅约10%见于外阴区域。颗粒细胞瘤在生命的第三个和第四个十年最为常见，在非裔美国人种族及女性中更为多见。一般来说，它们表现为小的、质地硬的、无痛的、生长缓慢的皮下结节。它们很少有包膜，复发很常见。恶性颗粒细胞瘤很少见，占病例的1%至2%。这种类型具有高度侵袭性，对治疗无反应，最终会致命。已经描述了第三种类型的颗粒细胞瘤，其具有良性病理特征，但临床表现为恶性。所有类型的首选治疗方法是广泛的局部手术切除。本文描述了一例典型的良性型颗粒细胞瘤病例。
