Ono M, Itoh C
Department of Clinical Pathology, Iwate Medical University, Morioka.
Rinsho Byori. 1996 Dec;44(12):1132-7.
Platelets are anucleated blood cells that play a fundamental role in the initiation of hemostasis. In addition to platelet adhesion to the extracellular matrix, aggregation or platelet-platelet interaction is a requisite event in hemostasis. Some glycoproteins on platelet membranes mediate adhesion platelets. The glycoprotein (GP) Ib/IX/V complex is important in platelet adhesion and the GPIIb/IIIa complex mediate platelet to platelet interaction. P-selectin is a member of the selectin family and is transferred from secretory granules to the surface of activated platelets. P-selectin may function to mediate the interaction between activated platelets and leucocytes. We reviewed structure, function, biological roles and clinical application of three platelet-associated adhesion molecules.
血小板是无核血细胞，在止血起始过程中发挥着重要作用。除了血小板与细胞外基质的黏附外，聚集或血小板 - 血小板相互作用是止血过程中的一个必要事件。血小板膜上的一些糖蛋白介导血小板黏附。糖蛋白（GP）Ib/IX/V复合物在血小板黏附中起重要作用，而GPIIb/IIIa复合物介导血小板间相互作用。P-选择素是选择素家族的一员，从分泌颗粒转移至活化血小板表面。P-选择素可能起到介导活化血小板与白细胞之间相互作用的功能。我们综述了三种血小板相关黏附分子的结构、功能、生物学作用及临床应用。
