Ikeda H
Third Department of Internal Medicine, Kurume University School of Medicine.
Nihon Rinsho. 1998 Oct;56(10):2493-9.
Platelet aggregation and thrombus formation secondary to plaque disruption at the sites of coronary atheroma play a prominent role in the pathophysiology of acute coronary syndromes. A fundamental role of cell adhesion molecules are implicated for the disease process of these syndromes. These adhesion molecules play a active role in cell-extracellular matrix interaction and cell-cell interaction at the first step of the thrombus formation at the culprit lesion of the coronary artery. A more comprehensive understandings of adhesion molecules and their functions may promote the development of potentially more effective therapeutic strategies for the syndromes. This review focuses on the role of platelet glycoprotein Ib, IIb/IIIa and P-selectin in the thrombotic process.
冠状动脉粥样硬化部位斑块破裂继发的血小板聚集和血栓形成在急性冠脉综合征的病理生理学中起重要作用。细胞黏附分子在这些综合征的疾病过程中具有重要作用。在冠状动脉罪犯病变血栓形成的第一步，这些黏附分子在细胞与细胞外基质相互作用以及细胞间相互作用中发挥积极作用。对黏附分子及其功能有更全面的了解可能会促进针对这些综合征开发出更有效的治疗策略。本综述重点关注血小板糖蛋白Ib、IIb/IIIa和P-选择素在血栓形成过程中的作用。
