Ikeda H, Murohara T
Department of Internal Medicine III, Kurume University School of Medicine.
Nihon Rinsho. 1999 Jul;57(7):1502-7.
A fundamental role of cell adhesion molecules are implicated for the disease process of acute coronary syndromes. Among adhesion molecules, platelet membrane glycoprotein Ib binds to the von Willebrand factor and thereby activates glycoprotein IIb/IIIa, resulting in platelet aggregation. P-selection is rapidly translocated onto the cell surface within minutes and adheres to a sialylated fucosylated carbohydrate structure, sialyl Lewis(x), on leukocytes. P-selectin mediates adhesion of leukocytes to the activated platelets. Thus, these platelet glycoproteins play a active role in cell-extracellular matrix interaction and cell-cell interaction at the first step of the thrombus formation at the culprit lesion of the coronary artery. The more comprehensive understandings of adhesion molecules and their functions may promote the more effective therapeutic strategies for the acute coronary syndromes.
细胞粘附分子的基本作用与急性冠状动脉综合征的疾病过程有关。在粘附分子中，血小板膜糖蛋白Ib与血管性血友病因子结合，从而激活糖蛋白IIb/IIIa，导致血小板聚集。P-选择素在几分钟内迅速转移到细胞表面，并与白细胞上的唾液酸化岩藻糖基化碳水化合物结构唾液酸Lewis(x)结合。P-选择素介导白细胞与活化血小板的粘附。因此，这些血小板糖蛋白在冠状动脉罪犯病变血栓形成的第一步中，在细胞与细胞外基质相互作用和细胞间相互作用中发挥积极作用。对粘附分子及其功能的更全面了解可能会促进急性冠状动脉综合征更有效的治疗策略。
