[Pharmacodynamic data on neuro-endocrine effects on the muscle tone of the dog Oddi's sphincter after vagotomy].

The authors examined in 20 dogs the effect of alpha- and beta-receptors blocking pharmaca on the duodenal papilla after truncal vagotomy. In another group bilateral adrenalectomy was carried out in order to clarify the effects of the neuroendocrine system. After vagotomy and adrenalectomy the tonus of the sphincter of bile papilla was lowered. After blocking the alpha-receptors and preceding vagotomy, the pressure in the common bile duct is barely influenced, whereas after blocking the beta-receptors pressure values rise beyond normal. Because of the tonus changes of the sphincter after blocking alpha-, resp. beta-receptors, the adrenergic beta-receptor plays the most important role controlling the pressure in choledochous duct. Consequently, drugs acting on adrenergic beta-receptor yield new valuable contributions to diagnosis and management of bile duct diseases. After vagotomy beta-receptors blocking agents must be avoided since they would favor formation of bile stones.