Schumann Z, Darup K, Rittmann K
Z Exp Chir. 1977 Aug;10(4):192-6.
The authors examined in 20 dogs the effect of alpha- and beta-receptors blocking pharmaca on the duodenal papilla after truncal vagotomy. In another group bilateral adrenalectomy was carried out in order to clarify the effects of the neuroendocrine system. After vagotomy and adrenalectomy the tonus of the sphincter of bile papilla was lowered. After blocking the alpha-receptors and preceding vagotomy, the pressure in the common bile duct is barely influenced, whereas after blocking the beta-receptors pressure values rise beyond normal. Because of the tonus changes of the sphincter after blocking alpha-, resp. beta-receptors, the adrenergic beta-receptor plays the most important role controlling the pressure in choledochous duct. Consequently, drugs acting on adrenergic beta-receptor yield new valuable contributions to diagnosis and management of bile duct diseases. After vagotomy beta-receptors blocking agents must be avoided since they would favor formation of bile stones.
作者对20只狗进行研究，观察了在迷走神经干切断术后，α和β受体阻滞剂对十二指肠乳头的作用。另一组进行双侧肾上腺切除术以阐明神经内分泌系统的作用。迷走神经切断术和肾上腺切除术后，胆管乳头括约肌的张力降低。在阻断α受体并先行迷走神经切断术后，胆总管压力几乎未受影响，而在阻断β受体后，压力值超过正常水平。由于阻断α或β受体后括约肌的张力发生变化，肾上腺素能β受体在控制胆总管压力方面起最重要作用。因此，作用于肾上腺素能β受体的药物为胆管疾病的诊断和治疗提供了新的有价值的方法。迷走神经切断术后必须避免使用β受体阻滞剂，因为它们会促进胆结石的形成。
