Polo kinase: the choreographer of the mitotic stage?
作者信息
Glover D M, Ohkura H, Tavares A
机构信息
Department of Anatomy & Physiology, University of Dundee, Scotland.
出版信息
J Cell Biol. 1996 Dec;135(6 Pt 2):1681-4. doi: 10.1083/jcb.135.6.1681.
Abstract
摘要
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Polo kinase: the choreographer of the mitotic stage?波罗蛋白激酶：有丝分裂阶段的编排者？
J Cell Biol. 1996 Dec;135(6 Pt 2):1681-4. doi: 10.1083/jcb.135.6.1681.
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Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis.哺乳动物Plk1在果蝇中的异源表达揭示了有丝分裂后期与Polo的差异。
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Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.Polo激酶和天冬氨酸蛋白酶是促进中心体有丝分裂组织活性所必需的。
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Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase.非洲爪蟾类Polo样激酶Plx1：一种多功能有丝分裂激酶。
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The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.Sak马球盒包含一个足以实现有丝分裂亚细胞定位的结构域。
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Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry.在有丝分裂进入时，Polo 激酶的激活与双功能核定位信号（NLS）的核定位偶联是必需的。
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Yeast polo-like kinases: functionally conserved multitask mitotic regulators.酵母 polo 样激酶：功能保守的多任务有丝分裂调节因子。
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Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1.靶向polo样激酶1的polo盒结构域的细胞可渗透、类药物小分子抑制剂的设计与合成。
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Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma.在主要的非霍奇金淋巴瘤中缺乏Polo样激酶1（Plk1）的肿瘤特异性过表达，且在鼻型NK/T细胞淋巴瘤中Plk1表达相对较低。
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Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.polo样激酶1底物识别的分子与结构基础：对中心体定位的影响
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Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.人源Polo样激酶3诱导的细胞周期阻滞和凋亡是通过微管完整性的扰动介导的。
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Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.有丝分裂磷酸化作用可阻止HMGN蛋白与染色质结合。
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A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.一种分离功能相互作用基因的新遗传方法：高plo1(+)依赖性突变体及其抑制子定义了裂殖酵母有丝分裂和细胞分裂途径中的基因。
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本文引用的文献
1
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.酵母细胞分裂周期的遗传控制：V. cdc 突变体的遗传分析。
Genetics. 1973 Jun;74(2):267-86. doi: 10.1093/genetics/74.2.267.
2
3
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.爪蟾卵提取物中一种Cdc25调节激酶Plx1的纯化与分子克隆
Science. 1996 Sep 6;273(5280):1377-80. doi: 10.1126/science.273.5280.1377.
4
Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.Prk是一种细胞因子诱导的人类蛋白丝氨酸/苏氨酸激酶，其表达在肺癌中似乎下调。
J Biol Chem. 1996 Aug 9;271(32):19402-8. doi: 10.1074/jbc.271.32.19402.
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Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1.Plk是一种M期特异性蛋白激酶，与一种类驱动蛋白CHO1/MKLP-1相互作用。
Mol Cell Biol. 1995 Dec;15(12):7143-51. doi: 10.1128/MCB.15.12.7143.
6
A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos.一种在合胞体果蝇胚胎后期后期 - 末期活跃的保守有丝分裂激酶。
Nature. 1993 Jun 17;363(6430):637-40. doi: 10.1038/363637a0.
7
A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.酿酒酵母G1细胞周期突变基因dbf4的一个多拷贝抑制基因编码一种蛋白激酶，并被鉴定为CDC5。
Mol Cell Biol. 1993 Jul;13(7):4445-57. doi: 10.1128/mcb.13.7.4445-4457.1993.
8
Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.PLK的诱导与下调，PLK是一种在增殖细胞和肿瘤中表达的人类丝氨酸/苏氨酸激酶。
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1736-40. doi: 10.1073/pnas.91.5.1736.
9
Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.与果蝇的polo基因相关的一个编码蛋白激酶的小鼠基因Plk的鉴定与克隆。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6. doi: 10.1073/pnas.90.11.4882.
10
Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.Sak是一种鼠源蛋白丝氨酸/苏氨酸激酶，与果蝇polo激酶相关，参与细胞增殖。
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6388-92. doi: 10.1073/pnas.91.14.6388.
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