一个远端缺失同源结构域基因对表皮分化的调控
Regulation of epidermal differentiation by a Distal-less homeodomain gene.
作者信息
Morasso M I, Markova N G, Sargent T D
机构信息
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
J Cell Biol. 1996 Dec;135(6 Pt 2):1879-87. doi: 10.1083/jcb.135.6.1879.
Abstract
The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation.
摘要
与远端缺失相关的同源结构域基因Dlx3在终末分化的小鼠表皮细胞中表达。该基因在转基因皮肤的基底细胞层中异位表达会导致严重异常的表皮表型，并导致围产期致死。受影响小鼠的基底细胞停止增殖，并表达了通常仅在表皮分化的最晚期才转录的聚丝蛋白原和兜甲蛋白基因。所有基底上层细胞类型均减少，角质层减少到单层。这些数据表明，Dlx3的错误表达导致基底细胞转化为更分化的角质形成细胞，表明这种同源蛋白是表皮分化的重要调节因子。
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