[头颈部表皮样癌中人类乳头瘤病毒与细胞DNA含量的关系]
[The relation between human papilloma virus and cellular DNA content in epidermoid carcinoma of the head and neck].
作者信息
Rodrigo Tapia J P, Alvarez Alvarez I, Martínez Sánchez J A, Lazo P S, Ramos S, Sampedro Nuño A, Suárez Nieto C
机构信息
Servicio de ORL, Hospital Central de Asturias, Universidad de Oviedo.
出版信息
Acta Otorrinolaringol Esp. 1996 Sep-Oct;47(5):343-7.
The relation between the presence of gene sequences of human papilloma virus (HPV) and the development of abnormalities in cellular DNA content was analyzed in 31 squamous-cell carcinomas of the head and neck. The integration of HPV types 16 and 6b by PCR and DNA content was studied by flow cytometry in 31 specimens from patients with squamous-cell carcinoma of the head and neck. Eighteen (58%) cases were aneuploid. HPV DNA was present in seven tumors (22.5%), five of then HPV-6b and two of them HPV-16. Aneuploidy correlated with poorly differentiated tumors. No correlation was found between HPV integration and either cellular DNA content or the degree of histological tumor differentiation. Therefore, the presence of HPV gene sequences did not seem to be associated with a higher incidence of aneuploidy in squamous-cell carcinoma of the head and neck.
在31例头颈部鳞状细胞癌中分析了人乳头瘤病毒（HPV）基因序列的存在与细胞DNA含量异常发展之间的关系。通过聚合酶链反应（PCR）研究了16型和6b型HPV的整合情况，并采用流式细胞术对31例头颈部鳞状细胞癌患者的标本进行了DNA含量研究。18例（58%）病例为非整倍体。7例肿瘤（22.5%）中存在HPV DNA，其中5例为HPV - 6b，2例为HPV - 16。非整倍体与低分化肿瘤相关。未发现HPV整合与细胞DNA含量或肿瘤组织学分化程度之间存在相关性。因此，HPV基因序列的存在似乎与头颈部鳞状细胞癌中非整倍体的较高发生率无关。
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