Skwarski K, Lee M, MacNee W
Oddziału Chorób Płuc Kliniki Chorób Wewnetrznych.
Pneumonol Alergol Pol. 1996;64(9-10):627-37.
Plasma Atrial Natriuretic Peptide (ANP) levels are elevated in patients wish chronic obstructive pulmonary disease (COPD) and can play a role in oedema formation. Plasma ANP levels measured in 60 patients with COPD were compared with results of pulmonary haemodynamics, with therapeutic response to treatment in the time of exacerbation of COPD and with physiologic status of patients with stable COPD. Plasma ANP levels did not correlate with right atrial and pulmonary artery pressure, but were significantly related with right ventricular end diastolic volume and with right ventricular wall volume measured by magnetic resonance imaging. Oxygen breathing (2 l/min by nasal prongs in 30 min.) did not change either mean pulmonary artery pressure or ANP levels. Among patients studied during an acute exacerbation of COPD, plasma ANP levels were higher in patients with oedema (302 +/- 185 pg/ml) than in patients without oedema (87 +/- 43 pg/ml). Oxygen therapy applied in one hour did not influence plasma ANP levels. Plasma ANP levels decreased during first three days of treatment in patients with oedema. This decrease was related to the body weight. In the group of patients with hypoxemia in stable COPD, plasma ANP levels (120 +/- 50 pg/ml) were higher in patients with the history of hypercapnia and oedema than in others (54 +/- 15 pg/ml).
慢性阻塞性肺疾病（COPD）患者的血浆心房利钠肽（ANP）水平升高，且可能在水肿形成中起作用。对60例COPD患者测定的血浆ANP水平与肺血流动力学结果、COPD加重期的治疗反应以及稳定期COPD患者的生理状态进行了比较。血浆ANP水平与右心房和肺动脉压力无关，但与右心室舒张末期容积以及通过磁共振成像测量的右心室壁容积显著相关。吸氧（经鼻导管2升/分钟，持续30分钟）既未改变平均肺动脉压力，也未改变ANP水平。在COPD急性加重期研究的患者中，有水肿的患者血浆ANP水平（302±185皮克/毫升）高于无水肿的患者（87±43皮克/毫升）。一小时的氧疗对血浆ANP水平无影响。有水肿的患者在治疗的前三天血浆ANP水平下降。这种下降与体重有关。在稳定期COPD低氧血症患者组中，有高碳酸血症和水肿病史的患者血浆ANP水平（120±50皮克/毫升）高于其他患者（54±15皮克/毫升）。
