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[吖啶的硫代、硫羰基和氧代衍生物的抗菌活性]

[The antimicrobial activity of thio-, thioxo- and oxo- derivatives of acridine].

作者信息

Novosad N V

出版信息

Mikrobiol Z. 1996 Jul-Aug;58(4):55-8.

PMID:8991595
Abstract

Antimicrobial activity of thio-, thioxo- and oxo- derivatives of acridine has been studied. It was shown, that the majority of compounds possesses the moderate antimicrobial activity. It was established, that acetic acid (6-nitroacridinil-9-thio), piperidine salt (2-ethoxi-6-nitroacridinil-9-thio) and ethyl ether (acridinil-9-thio) of acetic acid show the expressed anti-bacterial activity with respect to gram-positive bacteria. The ethyl ether (acridinil-9-thio) of acetic acid also actively suppresses the growth of similar yeast fungus.

摘要

研究了吖啶的硫代、硫羰基和氧代衍生物的抗菌活性。结果表明,大多数化合物具有中等抗菌活性。已确定,乙酸(6-硝基吖啶-9-硫代)、哌啶盐(2-乙氧基-6-硝基吖啶-9-硫代)和乙酸乙酯(吖啶-9-硫代)对革兰氏阳性菌表现出明显的抗菌活性。乙酸乙酯(吖啶-9-硫代)也能有效抑制类似酵母真菌的生长。

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