Babov K D, Shumakov V O, Bratus' V V
Fiziol Zh (1994). 1996;42(1-2):17-24.
The role of the coagulative blood system in initiation of acute coronary events was investigated on patients with different clinical forms of ischemic heart disease (IHD). The obtained results indicate that unstable angina (UA) and myocardial infarction (MI) are two independent forms of the acute IHD with distinct qualitative peculiarities. The most common feature of UA was an increase in the functional activity of platelets both in cases proceeded in MI and in uncomplicated cases. It means that these changes may be treated as the main pathogenic factor if UA but not as a mechanism of its transformation to MI. But high degree of the risk of MI development appears if these changes are combined with preceding significant disturbances in the haemostatic balance as a result of inhibition of the activity of anticoagulative and fibrinolytic blood systems. These data show that differentiation of the diagnosis between UA and MI in its initial stage and the choice of the treatment principles should be based on the careful investigation of the coagulative potential of blood and of its most important components.
针对患有不同临床类型缺血性心脏病（IHD）的患者，研究了凝血系统在急性冠状动脉事件起始过程中的作用。所得结果表明，不稳定型心绞痛（UA）和心肌梗死（MI）是急性IHD的两种独立形式，具有明显的质性特征。UA最常见的特征是，无论是在进展为MI的病例还是未并发MI的病例中，血小板的功能活性均增加。这意味着这些变化可被视为UA的主要致病因素，而非其转变为MI的机制。但是，如果这些变化与先前由于抗凝和纤溶血液系统活性受到抑制而导致的止血平衡显著紊乱同时出现，那么MI发生的风险程度就会很高。这些数据表明，在UA和MI的初始阶段进行诊断鉴别以及选择治疗原则时，应基于对血液及其最重要成分的凝血潜能进行仔细研究。
