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[通过完整动物血液化学发光指标预测个体放射敏感性]

[The prediction of individual radiosensitivity by the indices of blood chemiluminescence in intact animals].

作者信息

Pavlenko I O, Istomina H H, Kataievs'kyĭ Iu F, Chebotar'ov Ue Iu

出版信息

Fiziol Zh (1994). 1996;42(1-2):36-9.

PMID:8991713
Abstract

The possibility of prediction of individual radiosensitivity by the chemiluminescence test is considered in this paper. Chemiluminescence is the phenomena which reflects a lot of biochemical processes connected indirectly with radiosensitivity. It has been established that dependence of the animal mortality on the value of the knmax/knmin ratio (kn coefficients of free-radical reaction rates) is of the parabolic shape. This agrees with available data that animals with extreme deviations of homoeostasis characteristics from average values are more susceptible to radiation than animals with characteristics close to average ones. Thus, the characteristics k1, k2 and k3 can be recommended as the determinants when predicting the radiation injury result.

摘要

本文探讨了通过化学发光试验预测个体辐射敏感性的可能性。化学发光是一种反映许多与辐射敏感性间接相关的生化过程的现象。已经确定,动物死亡率与knmax/knmin比值(自由基反应速率的kn系数)之间的依赖关系呈抛物线形状。这与现有数据一致,即体内稳态特征与平均值偏差极大的动物比特征接近平均值的动物对辐射更敏感。因此,在预测辐射损伤结果时,可推荐将特征k1、k2和k3作为决定因素。

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