[血液淋巴系统肿瘤与农业工作：在意大利南部一个流行病学区域开展的病例对照研究]

[Tumors of the hemolymphopoietic tract and employment in agriculture: a case-control study carried out in an epidemiologic area in southern Italy].

作者信息

Assennato G, Ferri G M, Tria G, Porro A, Macinagrossa L, Ruggieri M

机构信息

Istituto Medicina del Lavoro, Università degli Studi di Bari.

出版信息

G Ital Med Lav. 1995 Jan-Nov;17(1-6):91-7.

PMID:8991832

Abstract

To evaluate the role of agricultural exposures in the development of lymphatic and haemopoietic tumors a population-based case-referent study has been carried out in three health districts of Southern Italy. All incident cases of leukemia, lymphoma and myeloma from 1 July 1987 to 30 June 1989, aged 14 years or more, have been identified (71 subjects). The control group is formed by subjects with other neoplasms. A Job Exposure Matrix, specific to 10 areas, to 6 major crops and to 4 calendar periods, was built for assessing pesticide exposure. To date 100 interviews (to the index subject or to proxies) have been carried out (26 cases and 74 referents). The odds ratio (OR) of hematologic malignancies for agricultural workers was 1.63 [95% Confidence Intervals (95% CI): 0.69-4.34] in the whole sample and 6.00 (95% CI: 1.21-25.52) in the female group. Significative increased risks have been observed for exposure to DDT and creolin (OR = 4.11; 95% CI: 1.16-14.55) and, for leukemia, for cattle breeders (OR = 6.38; 95% CI: 1.46-27.83).

摘要

为评估农业接触因素在淋巴造血系统肿瘤发生发展中的作用，在意大利南部的三个卫生区开展了一项基于人群的病例对照研究。已确定了1987年7月1日至1989年6月30日期间年龄在14岁及以上的所有白血病、淋巴瘤和骨髓瘤新发病例（71名受试者）。对照组由患有其他肿瘤的受试者组成。构建了一个针对10个地区、6种主要作物和4个日历时间段的工作接触矩阵，用于评估农药接触情况。迄今为止，已进行了100次访谈（针对索引受试者或代理人）（26例病例和74名对照）。在整个样本中，农业工人血液系统恶性肿瘤的比值比（OR）为1.63 [95%置信区间（95%CI）：0.69 - 4.34]，在女性组中为6.00（95%CI：|1.21 - 25.52）。观察到接触滴滴涕和杂酚油的风险显著增加（OR = 4.11；95%CI：1.16 - 14.55），对于白血病患者，养牛者的风险也显著增加（OR = 6.38；95%CI：1.46 - 27.83）。