来自八放珊瑚Telesto riisei的细胞毒性酰胺。
Cytotoxic amides from the octocoral Telesto riisei.
作者信息
Liyanage G K, Schmitz F J
机构信息
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
出版信息
J Nat Prod. 1996 Feb;59(2):148-51. doi: 10.1021/np960032t.
Two new acyl derivatives of beta-phenylethylamine, N-(2-phenylethyl)-9- oxohexadecacarboxamide (1) and N-(2-phenylethyl)-9-hydroxyhexadecacarboxamide (2), and two new tetrahydroxysterols, cholestane-3 beta, 5 alpha,6 beta-26-tetrol 27-acetate (3) and cholestane-3 beta, 5 alpha, 6 beta-26-tetrol (4), have been isolated from the coelenterate Telesto riisei collected in Chuuk, Federated States of Micronesia. Structures were determined from spectroscopic data. All new compounds were mildly toxic to murine leukemia cells (P-388) in culture.
从密克罗尼西亚联邦楚克收集的腔肠动物Telesto riisei中分离出两种新的β-苯乙胺酰基衍生物，N-(2-苯乙基)-9-氧代十六碳酰胺(1)和N-(2-苯乙基)-9-羟基十六碳酰胺(2)，以及两种新的四羟基甾醇，胆甾烷-3β,5α,6β-26-四醇27-乙酸酯(3)和胆甾烷-3β,5α,6β-26-四醇(4)。结构由光谱数据确定。所有新化合物对培养中的小鼠白血病细胞(P-388)有轻度毒性。
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