Zelaya F O, Chalk J B, Mullins P, Brereton I M, Doddrell D M
Centre for Magnetic Resonance, University of Queensland, St. Lucia, Australia.
Magn Reson Med. 1996 Apr;35(4):443-8. doi: 10.1002/mrm.1910350401.
A movable, actively decoupled surface coil has been employed to obtain a localized 1H NMR spectrum from the lumbosacral spinal cord of a live Lewis rat. A volume selective 'VOSY' normally spelled out as 'volume selective spectroscopy' spectroscopy pulse sequence that incorporates 'phase ramped' selective RF pulses, has been used to minimize random phase jitter in the NMR signal as a result of the large frequency shifts required to locate the voxel in the center of the cord while using intense gradient pulses. Spectra from 13-microliters voxels in healthy rats and in rats inoculated with guinea pig spinal cord and complete Freund's adjuvant, resulting in experimental autoimmune encephalomyelitis, are shown.
一种可移动的、主动去耦表面线圈已被用于从一只活体Lewis大鼠的腰骶脊髓获取局部1H NMR谱。一种体积选择性的“VOSY”（通常拼写为“volume selective spectroscopy”，即体积选择性光谱学）光谱脉冲序列，该序列包含“相位倾斜”选择性射频脉冲，已被用于最小化NMR信号中的随机相位抖动，这是由于在使用强梯度脉冲将体素定位在脊髓中心时需要较大的频率偏移所致。展示了来自健康大鼠以及接种豚鼠脊髓和完全弗氏佐剂（导致实验性自身免疫性脑脊髓炎）的大鼠中13微升体素的光谱。
