Schneider F, Grodd W, Machulla H J
Psychiatrische Klinik, Universität Düsseldorf.
Nervenarzt. 1996 Sep;67(9):721-9. doi: 10.1007/s001150050046.
Changes in regional cerebral blood flow (rCBF) during experimentally modified psychological activation can be measured using radioactive ligands with positron emission tomography (PET) and using magnetic resonance principles with functional magnetic resonance imaging (fMRI). With PET it is possible to determine not only rCBF, but also metabolic changes, as well as the density and binding of several neuroreceptors. This can be done in conjunction with psychological and pharmacological challenge. fMRI is an imaging technique for perfusion-based signal intensities of the brain which does not involve radioactivity and gives better anatomical and temporal resolution than PET. Under appropriate experimental conditions, subjects' behavior and experience can be modified while they are lying in a tomograph. These experiments can be used for the scientific investigation of cognitive constructs such as memory and attention, or emotional processes. In this review, both functional neuroimaging techniques are assessed.
在实验性改变的心理激活过程中，局部脑血流量（rCBF）的变化可以通过正电子发射断层扫描（PET）使用放射性配体来测量，也可以通过功能磁共振成像（fMRI）利用磁共振原理来测量。使用PET不仅可以确定rCBF，还可以确定代谢变化以及几种神经受体的密度和结合情况。这可以与心理和药理学挑战相结合来完成。fMRI是一种用于基于灌注的脑信号强度的成像技术，它不涉及放射性，并且比PET具有更好的解剖和时间分辨率。在适当的实验条件下，受试者躺在断层扫描仪中时其行为和体验可以被改变。这些实验可用于对诸如记忆和注意力等认知结构或情绪过程进行科学研究。在这篇综述中，对这两种功能神经成像技术进行了评估。
