Grodd W, Schneider F, Klose U, Nägele T
Abteilung für Neuroradiologie, Universität Tübingen.
Radiologe. 1995 Apr;35(4):283-9.
Changes in regional cerebral blood oxygenation during experimentally modified psychological activation can be measured with functional magnetic resonance imaging (fMRI). fMRI is a new imaging technique for perfusion-based signal intensities of the brain without the necessity of radioactivity and with superior anatomical and temporal resolution compared to positron emission tomography (PET). In this study a T2* FLASH sequence (TR 240ms, TE 60ms, slice thickness 4 mm, alpha = 40 degrees, matrix 64 x 128) was used to investigate changes in signal intensity within the temporal lobe and the amygdala during experimentally induced emotions. Visual stimuli of happy [sad] facial portraits were presented to volunteers to induce changes in the subjects' mood while lying in the tomograph. In agreement with a previous PET study, a significant increase in signal intensity in the left amygdala was found during induction of a sad mood, while no comparable effect was visible during induction of a happy mood.
通过功能磁共振成像（fMRI）可以测量在实验性改变的心理激活过程中局部脑血氧合的变化。fMRI是一种基于灌注的脑信号强度的新成像技术，无需放射性，与正电子发射断层扫描（PET）相比具有 superior anatomical and temporal resolution。在本研究中，使用T2* FLASH序列（TR 240ms，TE 60ms，层厚4mm，α = 40度，矩阵64×128）来研究在实验诱导情绪期间颞叶和杏仁核内的信号强度变化。向志愿者呈现快乐[悲伤]面部肖像的视觉刺激，以使受试者躺在断层扫描仪中时情绪发生变化。与先前的PET研究一致，在诱发悲伤情绪期间发现左杏仁核信号强度显著增加，而在诱发快乐情绪期间未观察到类似效果。
