Ono S, Hirose T, Shiba T, Kuriya K, Watanabe K
Department of Radiology, Miyazaki Medical College.
Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Mar;56(4):201-7.
We studied clinically ultrasound (US) hyperthermia system developed in Japan. The prototype system consists of a power delivery unit (0.5MHz frequency) and a coolded water bolus. The modified type has three frequency applicators (0.5, 1.0, 1.5MHz) with a secondary bolus. Thirty-four patients with recurrent or metastatic tumors located in the shallow tissues were treated. Fourteen patients (Group I) were treated with the prototype system and 20 patients (Group II) with the modified type. In 13 of the Group II patients, aluminum-urethane shields were used to protect nearby bone from overheating. The heating goal was 42.0 degrees C for at least 30 minutes in the tumor's center. The temperature was raised to 42.0 degrees C in 7 of 14 cases (50%) and in 17 of 41 sessions (41.5%) in Group I. In Group II the temperature was raised in 19 of 20 cases (95.0%) and in 67 of 80 sessions (83.7%). Response rates were 50.0% and 75.0% respectively in Groups I and II. The incidence of side effects including burn and ostalgia were 100% and 20% respectively in Groups I and II. These results suggest that the modified US hyperthermia system was valuable in clinical use.
我们研究了日本研发的临床用超声（US）热疗系统。该原型系统由一个功率输送单元（频率0.5MHz）和一个水冷式水囊组成。改进型有三个频率的 applicators（0.5、1.0、1.5MHz）以及一个辅助水囊。对34例浅部组织复发或转移性肿瘤患者进行了治疗。14例患者（I组）采用原型系统治疗，20例患者（II组）采用改进型治疗。II组中有13例患者使用了铝 - 聚氨酯防护罩来保护附近骨骼以免过热。加热目标是肿瘤中心温度达到42.0摄氏度并持续至少30分钟。I组中14例患者中有7例（50%）、41次治疗中有17次（41.5%）温度升至42.0摄氏度。II组中20例患者中有19例（95.0%）、80次治疗中有67次（83.7%）温度升高。I组和II组的有效率分别为50.0%和75.0%。I组和II组中包括烧伤和骨痛在内的副作用发生率分别为100%和20%。这些结果表明改进后的超声热疗系统在临床应用中有价值。
