Lehoux S, Plante G E
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Québec, Canada.
Prostaglandins Leukot Essent Fatty Acids. 1996 Jan;54(1):65-70. doi: 10.1016/s0952-3278(96)90083-6.
Arterial hypertension is associated with increased capillary permeability, a possible contributor to the vascular remodeling process which could be involved in certain pathological conditions arising from elevated blood pressure. This study evaluated the effects of various antihypertensive drugs on capillary permeability in the normal rat, using Evan's blue dye (EB) as a marker of albumin extravasation. The results reveal that acute injection of certain diuretics (furosemide, indapamide, hydrochlorothiazide) increase while others (amiloride, cicletanine) decrease capillary permeability via stimulation of the cyclooxygenase pathway. 10 day gavage with indapamide, amiloride and cicletanine, as well as angiotensin-converting enzyme (ACE) inhibitor perindopril and calcium channel blockers nifedipine and verapamil decreases capillary permeability, whereas furosemide, hydrochlorothiazide, ACE inhibitor captopril and calcium channel blocker clentiazem do not modify or increase EB extravasation. Hence, selected antihypertensive agents reduce capillary permeability and could therefore have a supplemental protective vascular effect, in addition to their lowering arterial pressure.
动脉高血压与毛细血管通透性增加有关，这可能是血管重塑过程的一个促成因素，而血管重塑可能与血压升高引起的某些病理状况有关。本研究使用伊文思蓝染料（EB）作为白蛋白外渗的标志物，评估了各种抗高血压药物对正常大鼠毛细血管通透性的影响。结果显示，急性注射某些利尿剂（呋塞米、吲达帕胺、氢氯噻嗪）会增加毛细血管通透性，而其他利尿剂（阿米洛利、环戊噻嗪）则通过刺激环氧化酶途径降低毛细血管通透性。连续10天用吲达帕胺、阿米洛利和环戊噻嗪以及血管紧张素转换酶（ACE）抑制剂培哚普利和钙通道阻滞剂硝苯地平和维拉帕米进行灌胃可降低毛细血管通透性，而呋塞米、氢氯噻嗪、ACE抑制剂卡托普利和钙通道阻滞剂克仑硫卓则不会改变或增加EB外渗。因此，所选的抗高血压药物可降低毛细血管通透性，因此除了降低动脉压外，还可能具有额外的血管保护作用。
