Köster R, Terres W, Hamm C, Kähler J, Meinertz T
Universitäts-Krankenhaus Eppendorf Medizinische Klinik und Poliklink, Hamburg.
Z Kardiol. 1996 Sep;85(9):640-6.
The AVE Micro Stent is a flexible stent with a small surface. Aim of this study was to investigate safety and efficacy of this stent. 105 AVE Micro Stents were deployed in 78 lesions in 64 patients. The implantation was performed electively (19%), after unsatisfactory PTCA (59%), and as "bailout" (23%) into left main (1), LAD (23), LCX (15), RCA (19) or CABG (6). Minimal lumen diameter and percent diameter stenosis were measured by quantitative coronary angiography before and after interventions and, in 21 patients, after 3 months. Stent-implantation was successful in 62 of 64 patients. The passage of the AVE Micro Stents through deployed stents (46) was successful in all of 28 cases. There were no deaths or myocardial infarctions. In two patients, subacute thromboses with subsequent increase of CK occurred, which were successfully treated. The minimal lumen diameter was 0.77 +/- 0.62 mm before intervention, 2.98 +/- 0.48 mm after implantation (p < 0.001), and 2.03 +/- 1.21 after 3 months (p < 0.001). The percent diameter stenosis was 75 +/- 20% before intervention, 39 +/- 20% after PTCA and 0 +/- 12% after implantation (p < 0.001). After 3 months, six of 21 patients (29%) with follow-up angiography had a restenosis, defined as > 50% diameter stenosis compared with the reference vessel.
AVE微型支架是一种表面较小的可弯曲支架。本研究的目的是调查该支架的安全性和有效性。在64例患者的78处病变中植入了105枚AVE微型支架。植入手术选择性进行（19%），在PTCA效果不满意后进行（59%），以及作为“补救”措施进行（23%），植入部位包括左主干（1处）、前降支（23处）、左旋支（15处）、右冠状动脉（19处）或冠状动脉搭桥术后病变（6处）。在干预前后以及21例患者术后3个月时，通过定量冠状动脉造影测量最小管腔直径和直径狭窄百分比。64例患者中有62例支架植入成功。28例AVE微型支架穿过已植入支架（46枚）的操作全部成功。无死亡或心肌梗死病例。2例患者发生亚急性血栓形成并随后出现肌酸激酶升高，经成功治疗。干预前最小管腔直径为0.77±0.62mm，植入后为2.98±0.48mm（p<0.001），3个月后为2.03±1.21mm（p<0.001）。干预前直径狭窄百分比为75±20%，PTCA后为39±20%，植入后为0±12%（p<0.001）。3个月后，21例接受随访血管造影的患者中有6例（29%）发生再狭窄，定义为与参照血管相比直径狭窄>50%。
1）AVE微型支架是一种可弯曲支架，即使穿过已植入的支架也能安全有效地植入。2）AVE微型支架似乎特别适合用于夹层的“补救”治疗。3）该支架的亚急性血栓形成发生率较低。
