Vershinina S V, Kolosova O A, Voznesenskaia T G
Zh Nevrol Psikhiatr Im S S Korsakova. 1996;96(3):38-40.
The more accurate definition of the role of cerebral mechanism in migraine development by means of contingent negative deviation (CND) method was the aim of this investigation. The significant alterations of some parameters were revealed in patients with migraine between the fits as compared with controls. The same indices were normal during the very fits. The CND indices were similar in patients with chronic Headache of strain and healthy individuals. The clinical neurophysiological analysis didn't reveal any significant dependence of CND changes clinical peculiarities and anxious and depressive disorders. The significant elevation of CND parameters observed between the attacks suggests presence of superfluous activity in cerebral structures (noradrenergic mainly) in patients with migraine without aura. Such alterations in their action lead, apparently, to headache attack development.
本研究旨在通过关联负变化（CND）方法更准确地界定脑机制在偏头痛发作中的作用。与对照组相比，偏头痛患者发作间期某些参数出现显著改变。而在发作期间，相同指标则正常。慢性紧张性头痛患者与健康个体的CND指标相似。临床神经生理学分析未发现CND变化与临床特征及焦虑和抑郁障碍之间存在任何显著关联。无先兆偏头痛患者发作间期观察到的CND参数显著升高表明，其脑结构（主要是去甲肾上腺素能结构）存在过度活动。显然，这些结构活动的改变会导致头痛发作。
