Whyte M P, Teitelbaum S L, Reinus W R
Department of Medicine, Jewish Hospital of St. Louis, Washington University School of Medicine, Missouri, USA.
J Bone Miner Res. 1996 Apr;11(4):554-8. doi: 10.1002/jbmr.5650110417.
A former intravenous substance abuser, seropositive for hepatitis C virus infection, was referred for diffuse osteosclerosis. There was no history of fracture or skeletal deformity. Cortical and trabecular bone density was approximately twice the mean value for controls. Skeletal histology revealed dense lamellar bone. Recognized causes of acquired generalized osteosclerosis or hyperostosis were excluded. This patient verifies the syndrome of painful diffuse osteosclerosis after intravenous drug abuse and shows that skeletal mass can be markedly increased with histologically normal, structurally sound bone during adult life. Elucidation of the etiology and pathogenesis could offer an effective treatment for osteoporosis.
一名曾静脉注射吸毒且丙型肝炎病毒感染血清学呈阳性的患者因弥漫性骨硬化前来就诊。患者无骨折或骨骼畸形病史。皮质骨和小梁骨密度约为对照组平均值的两倍。骨骼组织学检查显示为致密板层骨。已排除已知的获得性全身性骨硬化或骨质增生的病因。该患者证实了静脉吸毒后出现疼痛性弥漫性骨硬化综合征，并表明在成年期骨骼质量可在组织学正常、结构健全的情况下显著增加。阐明其病因和发病机制可为骨质疏松症提供有效的治疗方法。
