Losada J S
Med J Zambia. 1977 Jun-Jul;11(3):73-4.
Fifty-nine patients with malignant tumours on the head and neck area, were treated with continuous intra-arterial infusion of methotrexate into the external carotid artery from a catheter introduced through the superficial temporal artery. Each patient received intramuscular injections of folinic acid in a dosage of 6mg every 6 hours, and a total dose of 250mg of methotrexate during a five day treatment period. The patients had received no previous chemotherapy, radiotherapy nor surgery. Forty-four of the fifty-nine patients (74.5%) responded partially to treatment and three had complete remissions. No recurrence was observed after a follow-up of more than eight months. Twelve patients showed no response at all.
59例头颈部恶性肿瘤患者，通过经颞浅动脉插入的导管，将甲氨蝶呤持续动脉内输注至颈外动脉进行治疗。每位患者每6小时接受一次剂量为6mg的亚叶酸钙肌肉注射，在为期5天的治疗期间共接受250mg甲氨蝶呤。这些患者此前未接受过化疗、放疗或手术。59例患者中有44例（74.5%）对治疗有部分反应，3例完全缓解。随访超过8个月未观察到复发。12例患者完全没有反应。
