Finlay B B, Ruschkowski S, Kenny B, Stein M, Reinscheid D J, Stein M A, Rosenshine I
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
Ann N Y Acad Sci. 1996 Oct 25;797:26-31. doi: 10.1111/j.1749-6632.1996.tb52946.x.
Enteropathogenic E. coli (EPEC) is a leading cause of neonatal diarrhea worldwide. These organisms adhere to the intestinal cell surface, causing rearrangement in the epithelial cell surface and underlying cytoskeleton, resulting in a structure termed an attaching/effacing (A/E) lesion. A/E lesion formation is thought necessary for EPEC-mediated disease. EPEC secretes several proteins that trigger signal transduction, intimate adherence, and cytoskeletal rearrangements in epithelial cells. Additionally, it produces intimin, an outer membrane product that mediates intimate adherence. Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea.
肠致病性大肠杆菌（EPEC）是全球新生儿腹泻的主要病因。这些细菌附着于肠道细胞表面，导致上皮细胞表面和其下方的细胞骨架发生重排，形成一种称为紧密黏附/抹平（A/E）损伤的结构。A/E损伤的形成被认为是EPEC介导疾病所必需的。EPEC分泌多种蛋白质，这些蛋白质可触发上皮细胞中的信号转导、紧密黏附及细胞骨架重排。此外，它还产生一种介导紧密黏附的外膜产物——紧密素。这些不同的细菌分子共同促成了EPEC与宿主上皮细胞之间形成的紧密关系，进而导致A/E损伤的形成和腹泻。
