Braszko J J, Winnicka M M, Wiśniewski K
Department of Pharmacology, Medical Academy, Bialystok, Poland.
Acta Physiol Hung. 1996;84(1):63-72.
The influence of Solcoseryl (S), a protein-free extract of calves' blood given intraperitoneally (i.p.) on the behavioural measures of activity of the central nervous system of male Wistar rats was examined. The drug (1.0 ml/kg i.p.) given 60 min before testing the animals in electromagnetic motimeter significantly enhanced overall and vertical motility of rats. S at the doses of 0.5, 1.0 and 2.0 ml/kg did not significantly influence the activity of rats in "open field". 1.0 ml/kg of S given 15, 45 and 60 min before thiopental (30 mg/kg i.p.) did not change the onset and time of sleep following the latter drug, except for the significant shortening of the time of sleep of animals injected with S 15 min before thiopental. S at the dose of 1.0 ml/kg did not change stereotypies produced by apomorphine (2.0 mg/kg i.p.) and amphetamine (6.5 mg/kg i.p.) but decreased intensity of haloperidol (1.0 mg/kg i.p.) catalepsy.
研究了腹腔注射小牛血无蛋白提取物Solcoseryl（S）对雄性Wistar大鼠中枢神经系统行为活动指标的影响。在电磁活动计中对动物进行测试前60分钟腹腔注射该药物（1.0毫升/千克），可显著增强大鼠的整体活动和垂直活动能力。0.5、1.0和2.0毫升/千克剂量的S对大鼠在“旷场”中的活动没有显著影响。在硫喷妥钠（30毫克/千克腹腔注射）前15、45和60分钟给予1.0毫升/千克的S，除了在硫喷妥钠前15分钟注射S的动物睡眠时间显著缩短外，未改变后一种药物给药后的入睡时间和睡眠时间。1.0毫升/千克剂量的S未改变阿扑吗啡（2.0毫克/千克腹腔注射）和苯丙胺（6.5毫克/千克腹腔注射）引起的刻板行为，但降低了氟哌啶醇（1.0毫克/千克腹腔注射）引起的僵住症强度。
