Winnicka M M, Braszko J J, Wisniewski K
Department of Pharmacology, Medical Academy, Bialystok, Poland.
Acta Physiol Hung. 1996;84(1):55-62.
Our previous experiments have shown that Solcoseryl (S), a protein-free extract of calves' blood stimulates locomotor activity and decreases haloperidol catalepsy in rats. In this study the influence of S on acquisition, consolidation, and recall of both, conditioned avoidance responses (CARs) and passive avoidance behaviour was tested. S at the intraperitoneal (i.p.) dose of 1.25 ml/kg significantly improved acquisition and at the dose of 1.0 ml/kg recall of CARs. In the passive avoidance situation the significant effect on acquisition and recall of information was observed after i.p. injection of 1.0 ml/kg of S, and on consolidation after 0.75 ml/kg. These data indicate that S may positively affect the CNS processes responsible for learning and memory.
我们之前的实验表明，小牛血去蛋白提取物Solcoseryl（S）能刺激大鼠的运动活动，并减少氟哌啶醇引起的僵住症。在本研究中，测试了S对条件性回避反应（CARs）和被动回避行为的获得、巩固及回忆的影响。腹腔注射（i.p.）剂量为1.25 ml/kg的S显著改善了CARs的获得，剂量为1.0 ml/kg时改善了CARs的回忆。在被动回避实验中，腹腔注射1.0 ml/kg的S后，观察到对信息获得和回忆有显著影响，注射0.75 ml/kg时对巩固有显著影响。这些数据表明，S可能对负责学习和记忆的中枢神经系统过程产生积极影响。
