Levine P H
Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.
Biotherapy. 1996;9(1-3):77-9. doi: 10.1007/BF02628661.
Chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by severe prolonged unexplained fatigue and a variety of associated symptoms such as arthralgias, myalgias, cognitive dysfunction, and severe sleep disturbances. Many patients initially present with an acute onset of apparent infectious origin with either an upper respiratory or gastrointestinal illness, fever, chills, tender lymphadenopathy, and malaise suggestive of a flu-like illness. In some cases, specific viral infections can be identified at the outset, particularly herpes viruses such as Epstein-Barr virus (EBV), human herpes virus-6 (HHV-6), and cytomegalovirus (CMV). Transfer factors (TF) with specific activity against these herpes viruses has been documented. With some studies suggesting that persistent viral activity may play a role in perpetuation of CFS symptoms, there appears to be a rationale for the use of TF in patients with CFS and recent reports have suggested that transfer factor may play a beneficial role in this disorder. This report focuses on the heterogeneity of CFS, the necessity for randomized coded studies, the importance of patient selection and sub-classification in clinical trials, and the need to utilize specific end-points for determining efficacy of treatment.
慢性疲劳综合征（CFS）是一种异质性疾病，其特征为严重的长期不明原因疲劳以及多种相关症状，如关节痛、肌痛、认知功能障碍和严重睡眠障碍。许多患者最初表现为急性起病，貌似由感染引起，伴有上呼吸道或胃肠道疾病、发热、寒战、压痛性淋巴结病以及类似流感的不适。在某些情况下，一开始就能识别出特定的病毒感染，特别是疱疹病毒，如爱泼斯坦-巴尔病毒（EBV）、人疱疹病毒6型（HHV-6）和巨细胞病毒（CMV）。已证明存在针对这些疱疹病毒具有特异性活性的转移因子（TF）。一些研究表明，持续的病毒活性可能在CFS症状的持续存在中起作用，因此似乎有理由在CFS患者中使用TF；最近的报告表明转移因子可能在这种疾病中发挥有益作用。本报告重点关注CFS的异质性、随机编码研究的必要性、临床试验中患者选择和亚分类的重要性，以及利用特定终点来确定治疗效果的必要性。
