血管紧张素肽在延髓头端腹外侧区的作用

Functions of angiotensin peptides in the rostral ventrolateral medulla.

Dampney R A, Hirooka Y, Potts P D, Head G A

Department of Physiology, University of Sydney, New South Wales, Australia.

Clin Exp Pharmacol Physiol Suppl. 1996;3:S105-11.

Abstract

It was first shown several years ago that the rostral part of the ventrolateral medulla (VLM) contains a high density of receptor binding sites for angiotensin II (AngII). In the present paper we briefly review recent studies aimed at determining the actions of both exogenous and endogenous angiotensin peptides in the rostral VLM, as well as their specific sites of action. 2. The results of these studies have shown that angiotensin peptides can excite pressor and sympathoexcitatory neurons in the rostral VLM, but do not appear to affect non-cardiovascular neurons in this region. 3. It is known that pressor neurons in the rostral VLM include both catecholamine and non-catecholamine neurons. There is evidence that, at least in conscious rabbits, both of these types of neurons are activated by AngII. The specific endogenous angiotensin peptide or peptides that affect pressor neurons in the rostral VLM have not yet been definitively identified. 4. It is also possible that different angiotensin peptides may have different effects on pressor neurons in the rostral VLM, mediated by different receptors. Further studies will be needed to define these different functions as well as the specific receptors and cellular mechanisms that subserve them.

摘要

几年前首次发现，延髓腹外侧区（VLM）的嘴侧部分含有高密度的血管紧张素II（AngII）受体结合位点。在本文中，我们简要回顾了最近的研究，这些研究旨在确定外源性和内源性血管紧张素肽在嘴侧VLM中的作用及其具体作用位点。2. 这些研究结果表明，血管紧张素肽可兴奋嘴侧VLM中的升压和交感兴奋神经元，但似乎不影响该区域的非心血管神经元。3. 已知嘴侧VLM中的升压神经元包括儿茶酚胺能和非儿茶酚胺能神经元。有证据表明，至少在清醒兔中，这两种类型的神经元均被AngII激活。尚未明确鉴定出影响嘴侧VLM中升压神经元的具体内源性血管紧张素肽。4. 不同的血管紧张素肽也可能通过不同的受体对嘴侧VLM中的升压神经元产生不同的作用。需要进一步的研究来确定这些不同的功能以及发挥这些功能的特定受体和细胞机制。