Abe H, Terui S, Terauchi T, Muramatsu Y, Yokayama R, Ohtomo K, Beppu Y, Fukuma H
National Cancer Center of Japan, Department of Diagnostic Radiology, Tokyo, Japan.
Clin Nucl Med. 1997 Jan;22(1):38-41. doi: 10.1097/00003072-199701000-00009.
Tc-99m pertechnetate scintigraphy was compared with Tl-201 chloride and Ga-67 citrate to evaluate the avidity of Tc-99m pertechtate for malignant soft-tissue tumors. Twenty-three patients with malignant soft-tissue tumors underwent scintigraphic studies. All 23 received Tc-99m and Tl-201, whereas 14 also were injected with Ga-67. In 21 (91%) of the 23 patients, Tc-99m accumulated extensively in the tumors. Tl-201 accumulated in 12 (52%) of the 23 tumors. Ga-67 accumulated in only 5 (36%) of the 14 tumors. The avidity of Tc-99m for myxoid tumors was markedly different from the other two agents. Tc-99m accumulated in all eight myxoid tumors, while neither Tl-201 or Ga-67 showed marked accumulation except for one patient with increased accumulation of Tl-201. This study shows that Tc-99m pertechnetate has the potential to localize malignant soft-tissue tumors and may be useful in the evaluation of these tumors.
将锝-99m高锝酸盐闪烁显像与氯化铊-201和枸橼酸镓-67进行比较，以评估锝-99m高锝酸盐对恶性软组织肿瘤的摄取能力。23例恶性软组织肿瘤患者接受了闪烁显像研究。所有23例患者均接受了锝-99m和铊-201检查，其中14例还注射了镓-67。在23例患者中的21例（91%），锝-99m在肿瘤中大量聚集。铊-201在23个肿瘤中的12个（52%）中聚集。镓-67仅在14个肿瘤中的5个（36%）中聚集。锝-99m对黏液样肿瘤的摄取能力与其他两种药物明显不同。锝-99m在所有8个黏液样肿瘤中聚集，而铊-201和镓-67均未显示明显聚集，只有1例铊-201摄取增加的患者除外。本研究表明，锝-99m高锝酸盐有可能定位恶性软组织肿瘤，可能有助于这些肿瘤的评估。
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