用锝（Ⅴ）-99m二巯基丁二酸对软组织肿瘤进行成像。一种新型肿瘤寻踪剂。

Imaging of soft tissue tumors with Tc(V)-99m dimercaptosuccinic acid. A new tumor-seeking agent.

作者信息

Ohta H, Endo K, Fujita T, Nakajima T, Sakahara H, Torizuka K, Shimizu Y, Hata N, Masuda H, Horiuchi K

出版信息

Clin Nucl Med. 1984 Oct;9(10):568-73. doi: 10.1097/00003072-198410000-00007.

DOI:10.1097/00003072-198410000-00007

PMID:6091971

Abstract

Tumor scintigraphy, using Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS) was performed in 58 patients with soft tissue tumors, and the results were compared with that of Ga-67 citrate. Tc(V)-DMS was found to have a sensitivity of 90% for malignant tumors including aggressive fibromatosis compared to that of Ga-67 citrate, which was 56%. However, the specificity of Tc(V)-DMS for these tumors was 71% but with Ga-67 citrate the specificity was 80%. The imaging accuracy in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors, the reduced accumulation in inflammatory lesions compared to Ga-67 citrate was recognized, and Tc(V)-DMS could be of great use in the detection of extension or location of malignant soft tissue tumors.

摘要

对58例软组织肿瘤患者进行了使用锝（Ⅴ）-99m二巯基丁二酸（Tc（Ⅴ）-DMS）的肿瘤闪烁显像，并将结果与枸橼酸镓-67的结果进行比较。结果发现，与枸橼酸镓-67（敏感性为56%）相比，Tc（Ⅴ）-DMS对包括侵袭性纤维瘤病在内的恶性肿瘤的敏感性为90%。然而，Tc（Ⅴ）-DMS对这些肿瘤的特异性为71%，而枸橼酸镓-67的特异性为80%。使用Tc（Ⅴ）-DMS和枸橼酸镓-67对软组织肿瘤的显像准确性分别为78%和71%。尽管在一些良性软组织肿瘤中已检测到Tc（Ⅴ）-DMS的积聚，但与枸橼酸镓-67相比，其在炎症病变中的积聚减少，并且Tc（Ⅴ）-DMS在检测恶性软组织肿瘤的扩展或位置方面可能非常有用。