Demitsu T, Kosuge A, Yamada T, Usui K, Katayama H, Yaoita H
Department of Dermatology, Jichi Medical School, Tochigi-ken, Japan.
Dermatology. 1996;193(1):56-8. doi: 10.1159/000246204.
A 52-year-old woman, without a history of psoriasis, developed a widespread, sterile pustular eruption on the trunk and extremities 2 days after subcutaneous injection of dexamethasone solution. Skin biopsy revealed subcorneal pustules filled with neutrophils and moderate lymphohistiocytic infiltrate with a few eosinophils in the dermis. There was no evidence of vasculitis. Patch testing showed positive pustular reactions to dexamethasone solution. Histology of this pustule also resembled that of the original eruption. To our knowledge, acute generalized exanthematous pustulosis due to corticosteroid has not been previously reported.
一名52岁女性，既往无银屑病病史，在皮下注射地塞米松溶液2天后，躯干和四肢出现广泛的无菌性脓疱疹。皮肤活检显示角质层下脓疱内充满中性粒细胞，真皮有中度淋巴细胞和组织细胞浸润，并伴有少量嗜酸性粒细胞。无血管炎证据。斑贴试验显示对地塞米松溶液呈阳性脓疱反应。该脓疱的组织学表现也与最初皮疹相似。据我们所知，此前尚未有关于皮质类固醇引起急性泛发性发疹性脓疱病的报道。
