Somsen G A, van der Wall E E, van Vlies B, Borm J J, van Royen E A
Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
Int J Card Imaging. 1996 Dec;12(4):305-10. doi: 10.1007/BF01797744.
In patients with chronic heart failure, increased sympathetic activity and cardiac sympathetic neuronal dysfunction are present and have been related to unfavourable clinical outcome. Modification of these alterations with the objective to improve prognosis has become an important aim of pharmacological therapy for these patients. A noninvasive technique to assess sympathetic neuronal function at the cardiac level may be valuable in evaluating newly developed therapeutic strategies. 123-iodine metaiodobenzylguanidine can be used to visualize cardiac sympathetic nerve function and activity. Single photon emission computerized tomographic is preferred to planar scintigraphy since it does not depend on superposition of other anatomical structures and may allow assessment of regional cardiac 123-iodine metaiodobenzylguanidine uptake. Although the quantitation of cardiac uptake in these tomographic images has several limitations, the use of the left ventricular cavity as a reference, calibrated by the 123-iodine activity in a blood sample drawn at the time of acquisition, may have clinical applications, with respect to the evaluation of therapeutical intervention in patients with heart failure.
在慢性心力衰竭患者中，存在交感神经活动增加和心脏交感神经元功能障碍，且这与不良临床结局相关。通过改变这些异常以改善预后已成为这些患者药物治疗的重要目标。一种评估心脏水平交感神经元功能的非侵入性技术，对于评估新开发的治疗策略可能具有重要价值。123碘间碘苄胍可用于可视化心脏交感神经功能和活动。单光子发射计算机断层扫描优于平面闪烁显像，因为它不依赖于其他解剖结构的叠加，并且可以评估心脏局部对123碘间碘苄胍的摄取。尽管在这些断层图像中对心脏摄取进行定量存在一些局限性，但以采集时抽取的血样中的123碘活性进行校准，将左心室腔用作参考，在评估心力衰竭患者的治疗干预方面可能具有临床应用价值。
