Durany N, Thome J, Palomo A, Foley P, Riederer P, Cruz-Sánchez F F
Neurological Tissue Bank, Hospital Clinic, Barcelona, Spain.
Neurosci Lett. 1996 Dec 20;220(3):151-4. doi: 10.1016/s0304-3940(96)13251-1.
Dopamine receptors have long been implicated in the etiology of schizophrenia. It has been reported an association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus. We have investigated the distribution of a D3 receptor gene polymorphism (BalI) in 107 schizophrenic Spanish patients and 100 healthy matched controls. No statistically significant differences between the patients and control group were detected with respect to either allele frequencies or genotype distribution. However, if not corrected for multiple testing, a correlation was found between homozygosity and early age of onset of schizophrenia (chi 2 = 3.1, df = 1, P = 0.03) and between A1 allele frequency and disorganized and undifferentiated schizophrenia (chi 2 = 3.4, df = 1, P = 0.03; chi 2 = 2.7, df = 1, P = 0.05, respectively). These results suggest the possibility that D3 polymorphisms may be among the physiological factors underlying schizophrenia; though not the determining factor.
长期以来，多巴胺受体一直被认为与精神分裂症的病因有关。有报道称精神分裂症与多巴胺D3受体基因位点的纯合性有关。我们研究了107名西班牙精神分裂症患者和100名健康匹配对照中D3受体基因多态性（BalI）的分布情况。在等位基因频率或基因型分布方面，患者组和对照组之间未检测到统计学上的显著差异。然而，如果不进行多重检验校正，发现纯合性与精神分裂症的早发之间存在相关性（卡方 = 3.1，自由度 = 1，P = 0.03），以及A1等位基因频率与紊乱型和未分化型精神分裂症之间存在相关性（卡方分别为 = 3.4，自由度 = 1，P = 0.03；卡方 = 2.7，自由度 = 1，P = 0.05）。这些结果表明，D3多态性可能是精神分裂症潜在的生理因素之一；尽管不是决定性因素。
