Milrod B, Busch F
Cornell University Medical College, New York, New York 10021, USA.
J Nerv Ment Dis. 1996 Dec;184(12):723-30. doi: 10.1097/00005053-199612000-00002.
This review was designed to provide a detailed analysis of long-term outcome data from treatment studies for panic disorder, with the goal of ascertaining differential efficacy of the available treatments. Studies were included if they were published after 1980 and if follow-up took place at least 6 months after treatment termination. Thirty-one studies were located. A variety of methodological problems were found in these studies, including lack of clarity of diagnosis, lack of clarity in the treatment administered, and inadequately tracked nonstudy treatments during the study and follow-up periods, which limited the information that could be obtained about long-term outcome. Long-term outcome studies that closely track the additional treatments that patients receive are necessary to draw more definitive conclusions about differential treatment efficacy for panic disorder. Available data suggest that there is limited evidence for long-term maintenance of short-term treatment gains in panic disorder patients in the absence of continued treatment.
本综述旨在对惊恐障碍治疗研究的长期结果数据进行详细分析，目的是确定现有治疗方法的不同疗效。若研究发表于1980年之后且随访在治疗结束后至少6个月进行，则纳入该研究。共找到31项研究。这些研究存在多种方法学问题，包括诊断不明确、所实施治疗不明确，以及在研究和随访期间对非研究治疗的跟踪不足，这限制了可获得的关于长期结果的信息。要就惊恐障碍不同治疗方法的疗效得出更明确的结论，有必要开展长期结果研究，密切跟踪患者接受的额外治疗。现有数据表明，在没有持续治疗的情况下，惊恐障碍患者短期治疗效果的长期维持证据有限。
