Albus M, Scheibe G, Scherer J
State Mental Hospital Haar, Germany.
J Affect Disord. 1995 May 17;34(2):109-15. doi: 10.1016/0165-0327(95)00007-a.
50 patients with panic disorder (30 without and 20 with concomitant depression) were enrolled in a controlled treatment study using either imipramine or doxepin in addition to supportive psychotherapy and were then studied under naturalistic treatment conditions over a 5-year period. While patients with concomitant depression scored higher in overall measures of illness severity (as measured by HAMA, HAMD and GAS), no differences were detected between the groups with regard to panic disorder symptoms and degree of impairment. Our data suggest that comorbidity of panic disorder and depression is no prerequisite for poorer long-term outcome compared with panic disorder without depression.
50名惊恐障碍患者（30名无伴发抑郁，20名伴发抑郁）被纳入一项对照治疗研究，除支持性心理治疗外，使用丙咪嗪或多塞平进行治疗，然后在自然治疗条件下进行了为期5年的研究。虽然伴发抑郁的患者在疾病严重程度的总体测量指标（通过汉密尔顿焦虑量表、汉密尔顿抑郁量表和大体评定量表测量）上得分更高，但在惊恐障碍症状和损害程度方面，两组之间未发现差异。我们的数据表明，与无抑郁的惊恐障碍相比，惊恐障碍与抑郁的共病并非长期预后较差的先决条件。
