Ho A, Chan H, Tse K S, Chan-Yeung M
Department of Medicine, University of British Columbia, Canada.
Thorax. 1996 Dec;51(12):1280-2. doi: 10.1136/thx.51.12.1280.
Immediate hypersensitivity reactions ranging from mild urticaria to life threatening anaphylaxis after exposure to natural rubber latex have been reported frequently in health care workers while occupational asthma due to latex exposure is less well studied. The results of specific challenge tests and immunological tests in four health care workers with work related respiratory and skin disorders induced by the use of latex gloves are described. Occupational asthma was confirmed in three subjects by specific challenge tests. All had a positive skin test reaction to the latex extract; specific IgE antibodies were detected in only one subject. The fourth subject had a negative specific inhalation and skin test reaction to the latex extract. Peak expiratory flow monitoring at work and away from work showed a pattern consistent with work related asthma. These findings confirm that latex is a cause of occupational asthma in health care workers.
医护人员接触天然橡胶乳胶后，常出现从轻度荨麻疹到危及生命的过敏反应等速发型超敏反应，而因接触乳胶导致的职业性哮喘研究较少。本文描述了4名因使用乳胶手套而出现与工作相关的呼吸和皮肤疾病的医护人员进行特异性激发试验和免疫检测的结果。通过特异性激发试验，3名受试者被确诊为职业性哮喘。所有人对乳胶提取物的皮肤试验反应均呈阳性；仅在1名受试者中检测到特异性IgE抗体。第四名受试者对乳胶提取物的特异性吸入和皮肤试验反应均为阴性。在工作时和非工作时进行的呼气峰值流速监测显示出与职业性哮喘相符的模式。这些发现证实乳胶是医护人员职业性哮喘的一个病因。
