Kessler R E
Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA.
Clin Infect Dis. 1997 Jan;24 Suppl 1:S146-7. doi: 10.1093/clinids/24.supplement_1.s146.
This paper presents an overview of the potential chemotherapeutic approaches to antibiotic resistance, what those approaches have achieved, and future avenues of exploration. Chemical modifications of existing agent classes, interference with resistance mechanisms, searches for inhibitors of novel targets, and alternatives to chemotherapy with low-molecular-weight molecules are discussed. The research focusing on novel targets and on alternative approaches is most likely to yield breakthroughs against problem organisms in the future.
本文概述了针对抗生素耐药性的潜在化疗方法、这些方法已取得的成果以及未来的探索途径。讨论了现有药物类别的化学修饰、对耐药机制的干扰、寻找新靶点的抑制剂以及用低分子量分子替代化疗的方法。专注于新靶点和替代方法的研究最有可能在未来针对有问题的微生物取得突破。
